NABsys aims to make whole-genome DNA sequencing fast, inexpensive, and accurate enough to be used in clinical care. Our approach builds on existing solid-state technologies to create a whole-genome sequencing technology that employs electronic detection, does not depend on a polymerase, and directly obtains DNA sequence information over hundreds of thousands of bases.

Electronic Detection

Electronic detection allows for high speed, high sensitivity single-molecule analysis. Our electronic approach allows for single-molecule detection with a signal-to-noise ratio that is an order of magnitude higher than the world’s most advanced optical sequencing technologies.

Solid-State Technology

By using all solid-state materials, NABsys is able to build on the incredible advances in the semiconductor industry that have taken place over the last half-century. By applying semiconductor fabrication technology to the bioanalytical arena, NABsys has created a dramatically new way of sequencing DNA.

Polymerase-Free

Other sequencing technologies depend on enzymes known as polymerases to aid their sequencing platforms. Dependence on polymerases leads to problems in the performance of these platforms. NABsys has completely eliminated polymerase from its sequencing technology.

Long-Range Sequence Information

Other DNA sequencing technologies are processive and accumulate error as they go. As a result, they are limited to obtaining information about DNA sequences in small bits known as “reads.” The shorter these “read lengths” the greater the difficulty created for the associated sequencing platform. Because the NABsys approach is not processive, our DNA sequencing technology has no read-length associated limitations.

NABsys is a life sciences company working at the intersection of physics, biology, and computer science to revolutionize medicine through clinical-grade whole-genome DNA sequencing. NABsys is one of five companies to receive a “$1000 Genome” award from the National Human Genome Research Institute of the National Institutes of Health.