Electronic Genome Mapping for Verifying Somatic Structural Variants

Structural variants (SVs) are critical drivers of cancer initiation, progression, and therapeutic resistance. Yet, verifying larger SVs—beyond 300 base pairs—remains difficult using sequencing or cytogenetic methods alone.
This poster demonstrates how Electronic Genome Mapping (EGM) on the OhmX™ Platform independently verified hundreds of high-confidence somatic SVs in tumor-derived cell lines, including complex insertions and deletions.

Key insights from the poster:‍

• Independent validation of SVs across a wide size range, from 300 bp to several megabases
• High concordance with long-read sequencing, while confirming difficult-to-validate variants
  
• Use of ultra-long, native double-stranded DNA for improved accuracy
• A streamlined, cost-effective workflow suitable for translational cancer research

By serving as a powerful complementary technology, EGM strengthens confidence in somatic SV analysis and advances the study of cancer genomics.

Download the poster now to explore how EGM delivers reliable verification of structural variants.