Tech Notes

Improving Electronic Genome Mapping Genome Coverage With CRISPR/Cas9

Discover how CRISPR/Cas9 enhances genome coverage, accuracy, and flexibility in Electronic Genome Mapping (EGM)

EGM has already revolutionized how structural variants and long-range DNA features are detected—but what if you could go even further?

In this technical note, you'll learn how the strategic use of CRISPR/Cas9:

  • Overcomes limitations of traditional nicking protocols to expand genome coverage
  • Improves data quality by minimizing double-strand breaks and proximity errors
  • Enables precise, customizable tagging for high-resolution mapping
  • Streamlines workflows through temperature-controlled multiplexing
  • Opens the door to novel applications like targeted selection and multiplexed detection—all without costly optical systems

Whether you're working in genome assembly, structural variant analysis, or translational genomics, learn how CRISPR-based enhancements can take your mapping capabilities to the next level.

Download this technical note to learn more!

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Research Areas & Applications

Cancer Research
Genomic structural variations (SVs) encompass a diverse array of alterations involving large segments of the genome, such as deletions, duplications, inversions, translocations, and insertions.
Long-Read Sequencing Validation
Gain confidence in your genomic discoveries from long-read sequencing (LRS) platforms with a low-cost solution to verify, clarify, and identify structural variant (SV) calls.
Rare Disease
Structural variants are essential for diagnosing many genetic disorders and understanding their inheritance patterns.
Cell and Gene Therapy
In many patients, accurate detection and characterization of SVs are crucial for understanding disease etiology, developing targeted therapies, and designing effective gene delivery vectors.

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