Electronic Genome Mapping of Somatic Structural Variants in Tumor Cell Line

Structural variants (SVs) drive cancer development and drug resistance, yet remain challenging to detect and validate with traditional sequencing technologies. This poster demonstrates how Electronic Genome Mapping (EGM) independently verifies complex somatic SVs in tumor-derived cell lines across a broad size range—from 300 base pairs to several megabases.

Using Nabsys’ OhmX™ Platform, researchers validated 420 of 592 high-confidence insertions and deletions previously identified through multiple sequencing technologies. EGM’s superior resolution, streamlined workflow, and cost-effectiveness make it a powerful complementary method for confirming structural variants and resolving discordant calls across long-read sequencing platforms.

Explore how EGM enhances accuracy in cancer genomics and provides a reliable foundation for advancing structural variant research.